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Evidence-Based Stem Cell Therapy

Backed by 25 Years of Science and Research

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What are stem cells?

Inside the human body are hundreds of different types of cells that fulfill specific tasks and are responsible for maintaining its everyday function. Among these are stem cells, responsible for tissue repair and regeneration (also known as tissue remodeling) to maintain a healthy body.

Stem cells can self-renew by dividing to generate more stem cells of the same type. They can also differentiate into specialized cell types. Scientific evidence shows mesenchymal stem cells are safe and effective for treating a wide range of diseases and conditions.

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Scientific and
Clinical Studies

  • Scientific Presentations
  • Our Patient-Reported Outcomes
  • Published Research
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At Reju Stem Cells we use Wharton’s
jelly-derived mesenchymal stem cells
(WJ-MSCs) for our therapies.

Stem cells are adult/somatic cells that can be obtained from many different sources, such as bone marrow, adipose tissue, umbilical cords, and the placenta.

We use umbilical cord-derived mesenchymal stem cells, specifically from the Wharton’s jelly tissue (WJ-MSCs), as they are known to be among the most effective and have:

Exhibit exceptional
regenerative properties

Lowers pro-inflammatory cytokines, boosts anti-inflammatory cytokines, and releases exosomes for anti-inflammatory action.

Growth factors stimulate repair and regeneration of muscles, tendons, ligaments, discs, cartilage, and more.

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Allogeneic Therapies

Allogeneic MSCs are derived from screened donors and prepared for use without requiring a patient’s own cells. This approach allows for standardized preparation methods and consistent quality controls across batches.

All protocols are designed with patient safety, regulatory awareness, and responsible laboratory practices in mind.

Reju Stem Cells Signature Cells Quality Control and Attributes

Screening

Although donors are screened for health issues, the cells extracted from umbilical cords are then tested for specific proteins and genes that research has identified offer high potential for effective treatment.

Purification

Cells that pass screening tests are purified and expanded so that therapy can be prepared that contains millions of high-potency cells that the body can use to promote healing, modulate the immune system, and reduce inflammation.

Ongoing Testing

Cells are tested as they are expanded and “passaged” into larger containers. Once expansion is complete, cells are tested again to verify that they meet various markers and criteria for purity and potency.

Cryo-Preservation

After cells have been expanded and tested, they are frozen in our cell bank. When reactivated, they are tested once more to ensure quality and viability.

Three mechanisms of how these cells can work are:

  • Anti-inflammatory and angiogenesis through paracrine activity

 

  • Stabilize and repair damaged native cells through mitochondrial transfer and growth factors

 

  • Regenerate new tissue through exosome secretion to signal the body’s response to damage.

What are the benefits

The use of WJ-MSCs has significant advantages over bone marrow or adipose-derived MSCs, such as:

Rather than replacing damaged tissue directly, MSCs are studied for how they communicate with surrounding cells. This includes signaling that may support immune balance, inflammation response, and tissue environment regulation.

Research continues to examine how these cellular interactions may contribute to broader regenerative processes.

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What are hypoxia-conditioned mesenchymal stem cells?

Recent research on how stem cell therapy works gives scientists new insights that may help improve patient outcomes. Some studies demonstrate that adding exosomes to treatment protocols offers high therapeutic potential for some degenerative and age-related conditions, including chronic joint disease and skin aging.

Exosomes are naturally occurring extracellular vesicles in all types of cells, including mesenchymal stem cells (MSCs). They act as signaling agents, influencing other cells in the body by releasing:

  • Anti-inflammatory cytokines
  • Growth factors to promote healing
  • Specific proteins that enhance cellular repair

Research demonstrates that not only does adding exosomes help enhance the repair of damage, but they also act quickly. This is why some patients receiving exosomes report more immediate relief of symptoms, and then continued improvement until they experience the full benefits of the MSCs they receive.

 

Exosomes are applied in the same manner and time as MSCs, so there are no additional procedures or injections required. At Reju Stem Cells, we isolate exosomes as we culture MSCs from umbilical cord tissue, and concentrate them at our on-site lab to provide the highest possible potency.

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What are MSC exosomes?

A type of molecules secreted by MSCs, exosomes release anti-inflammatory cytokines, growth factors and proteins to control inflammation and repair damaged cells.

Recent research on how stem cell therapy works gives scientists new insights that may help improve patient outcomes. Some studies demonstrate that adding exosomes to treatment protocols offers high therapeutic potential for some degenerative and age-related conditions, including chronic joint disease and skin aging.

Exosomes are naturally occurring extracellular vesicles in all types of cells, including mesenchymal stem cells (MSCs). They act as signaling agents, influencing other cells in the body by releasing:

Anti-inflammatory cytokines

Growth factors to promote healing

Specific proteins that enhance cellular repair

Research demonstrates that not only does adding exosomes help enhance the repair of damage, but they also act quickly. This is why some patients receiving exosomes report more immediate relief of symptoms, and then continued improvement until they experience the full benefits of the MSCs they receive.

Exosomes are applied in the same manner and time as MSCs, so there are no additional procedures or injections required. At Reju Stem Cells, we isolate exosomes as we culture MSCs from umbilical cord tissue, and concentrate them at our on-site lab to provide the highest possible potency.

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At reju Stem Cells, we offer advanced protocols using both hypoxic and normoxic MSCs in our treatment protocols.

In both cases, we use Wharton’s jelly umbilical-cord derived mesenchymal stem cells (WJ-MSC). Research shows both the hypoxic and normoxic cells demonstrate exceptional anti-inflammatory properties, immune modulating capacity, and promote tissue repair and regeneration.

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Precision Stem
Cell Applications

Our Protocols to Precisely
Target Treatment Areas

MSC therapy has been studied worldwide for more than 50 years. Research demonstrates the safety and efficacy of mesenchymal stem cell treatments and their regenerative and anti-inflammatory capacity in pathologies such as:

  • Arthritis and orthopedic injuries
  • Neurologic diseases and disorders
  • Dermatologic conditions
  • Gastrointestinal disorders
  • Urologic disorders
  • Rheumatologic and autoimmune conditions
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Most patient protocols include at least one intravenous (IV) WJ-MSC infusion. For this simple procedure, cells are infused intravenously to allow them to circulate throughout the body.

Other treatment protocols include direct injection at specific treatment sites. When appropriate, our physicians use advanced imaging technology such as X-ray fluoroscopy and diagnostic ultrasound to guide cells to these sites precisely. Depending on the condition being treated, these injections can include:

  • Intralesional: Injection of cells directly into soft tissues.
  • Intraarticular: Injection of cells directly into a joint, commonly used to treat arthritis or orthopedic injuries (does not require sedation).
  • Intradiscal: Injection of cells into discs and facets of the spine (requires sedation).
  • Intrathecal: Injection of cells directly into the spinal canal, usually requiring local anesthesia.
  • Intradermal: Injection of cells directly into the dermal layer of the skin.
  • Intracavernous: Application directly into the cavernous bodies of the penis.
  • Intratesticular
  • Intraovarian
  • Intraprostatic
  • Intracystic/bladder

Patient-Centered Care Model

Our process is designed to ensure patients speak with trained professionals at the appropriate stage of their journey. This allows for focused consultations, clear communication, and a more streamlined experience from inquiry to care coordination.

treatment Protocols

  • Zigna Genix Treatment Protocols
  • Degenerative Disc Disease
  • Knee Osteoarthritis
  • Shoulder & Elbow Overuse Injuries
  • Spinal Cord Injuries
  • Tendinopathies
  • Erectile Dysfunction

Clinical Care Program

  • Regular follow-up: patients not included in research protocols
  • Research follow-up; patients included in search protocols
  • Specific follow-up period for each protocol
  • Patient educational interventions

Case Studies and
Case Reports

Observational
Research Protocols

  • Zigna Genix Treatment Protocols
  • Degenerative Disc Disease
  • Knee Osteoarthritis
  • Shoulder & Elbow Overuse Injuries
  • Spinal Cord Injuries
  • Tendinopathies
  • Erectile Dysfunction

Clinical Trials

  • COVID 19
  • Spinal Cord Injury
  • Concussion

treatment Protocols

  • Zigna Genix Treatment Protocols
  • Degenerative Disc Disease
  • Knee Osteoarthritis
  • Shoulder & Elbow Overuse Injuries
  • Spinal Cord Injuries
  • Tendinopathies
  • Erectile Dysfunction

Clinical Care Program

  • Regular follow-up: patients not included in research protocols
  • Research follow-up; patients included in search protocols
  • Specific follow-up period for each protocol
  • Patient educational interventions

Case Studies and
Case Reports

Observational
Research Protocols

  • Zigna Genix Treatment Protocols
  • Degenerative Disc Disease
  • Knee Osteoarthritis
  • Shoulder & Elbow Overuse Injuries
  • Spinal Cord Injuries
  • Tendinopathies
  • Erectile Dysfunction

Clinical Trials

  • COVID 19
  • Spinal Cord Injury
  • Concussion

Research and Innovation

Rejuscience, a subsidiary of Reju Stem Cells, is responsible for planning and executing our research and innovation activities aimed at identifying specific knowledge gaps in the field of regenerative medicine.

Our Methodology

The Rejuscience team develops and publishes meta-analyses and systematic reviews to combine peer-reviewed literature, case studies, and observational data in the creation of best practice, patient-specific protocols that include MSC therapy with complementary therapies. Together, optimal patient outcomes are achieved with improvements in pain, function, and quality of life.

Our Evidence-Based
Care Protocols

Our commitment to patient health is underscored by the rigorous integration of scientific evidence into our treatment protocols. We ensure that our treatment strategies meet the highest standards of scientific scrutiny based on global scientific evidence.

Our approach to healthcare is distinguished by evidence-based care protocols meticulously designed to address various medical conditions.

  • Dermatological conditions
  • Orthopedic/musculoskeletal disorders
  • Degenerative disc and spine disorders
  • Neurological disorders
  • Rheumatologic and autoimmune diseases
  • and other medical conditions
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Our Outcomes

Our research results in the most innovative treatments and
optimal patient outcomes in regenerative medicine:

  • Development of the highest potency Wharton’s jelly umbilical cord MSCs
  • The use of highly concentrated exosomes to complement MSC therapy
  • Internationally recognized research publications and presentations
  • 97% patient satisfaction after post-treatment survey
  • Published patient-reported outcomes
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References

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Real People. Real Results.

Meet patients who now enjoy better health, more energy, less pain, and get more out of life thanks to advanced stem cell therapy for autoimmune and degenerative conditions.

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